Issue : 01 DOI :
INTERNATIONAL
JOURNAL
OF
DIAGNOSTICS
AND
RESEARCH
Volume : 02
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9
Abstract
Background:TamakaShvasa(w.s.r. to Bronchial asthma) is characterized by difficulty in breathing, which
is due to the result of obstructed PranavahaSrotasa. In this clinical study AmrutadiVati is taken from
Chakradatta HikkaShvasaChikitsaPrakranam and VasadiVati is taken from YogaratnakarShvasaChikitsa
Adhyaya. In classics Both the drugs were mentioned in the form of Kvatha(Decoction). But here the
formulations are considered in the form of VatiKalpana. Aim:To evaluate and compare the clinical effect
of Amrutadivati and Vasadivati in Tamakashvasa. Materials&Methods-Simple Random Sampling method
was used for selection of patients. In Group-A(n=41) patients were treated with AmrutadiVati [2tab.
(500mg.each) thrice a day] with Anupana of luke warm water for 8weeks. In Group-B(n=34) patients were
treated with VasadiVati in similar dose,duration,Anupana. Followup was done for 4weeks in both groups.
Effect of therapy was assessed by Classical symptomatology of Tamaka Shvasa, cardinal symptoms of
Bronchial asthma and by Spirometry. Result:In Group-A results were found in Shvasa kashtata(51.39%),
decreasing dose of emergency medicine used/week(56.47%), Kasa (productive)(69.23%), Kasa(dry)(90%)
with marked improvement in 41.67%, moderate improvement in 30.56% patients. In Group-B results were
found in Shvasakashtata(55.38%),decreasing dose of emergency medicine used/week(65.6%),
Kasa(productive)(72.22%), Kasa(dry)(50%)with moderate improvement in 45.16% and marked
improvement in 29.03% patients. Conclusion:Amrutadivati and Vasadivati would be useful in
KaphapradhanaSampratijanya Tamaka Shvasa.
Keywords – Amrutadi vati, Bronchial asthma, Tamaka Shvasa, Vasadi vati
P
ISSN No. : 2584-2757
Volume : 03
Issue : 01
DOI
: 1 0 . 5 2 8 1 / z e n o d o . 1 7 3 5 8 6 88
Reg. No. : MAHA-703/16(NAG)
Year of Establishment – 2016
INTERNATIONAL JOURNAL OF DIAGNOSTICS AND RESEARCH
Corresponding author: Dr. Kapadiya Parul R.
Article Info: Published on : 15/10/2025
Impact Factor : 1.013
A Clinical Study of Amrutadi Vati And Vasadi Vati
In The Management of Tamaka Shvasa W.S.R. To Bronchial Asthma
Dr.Kapadiya Parul R.
1
, Dr.Dave Alankruta R.
2
1
Professor, Rognidan evam vikriti vigyan, Nootan Ayurvedic College and Research Centre, Sankalchand Patel
University, Visnagar, Gujarat, India
2
Ex.Asso. Prof. & I/C H.O.D., Dept. of Kayachikitsa I.P.G.T. & R.A., Gujarat Ayurved University, Jamnagar
Cite this article as: - Dr. Kapadiya Parul R .(2025) ; A Clinical Study of Amrutadi Vati And Vasadi VatiIn The Management of
Tamaka Shvasa W.S.R. To Bronchial Asthma;Inter .J. Dignostics and Research 3 (1) 9-21 , DOI :1 0 . 5 2 8 1 / z e n o d o . 1 7 3 5 8 6 88
G
A
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Introduction :
Shvasa Roga may be defined simply as a disease in
which the respiration and exchange of air is
disturbed. Shvasa is classified in following types-
Maha Shvasa, Urdhva Shvasa, Chhinna Shvasa,
Tamaka Shvasa, Kshudra Shvasa. In which
Tamaka Shvasa is a Svatantra Vyadhi (Independent
disease) and having its own etiology, pathology and
management. It is mentioned as Yapya
Vyadhi(Manageable disease). Acharya Charaka has
given separate Samprapti (Pathogenesis) of
Tamaka Shvasa along with the general Samprapti
of Shvasa Roga. This study focuses only on
Tamaka Shvasa. Ayurveda refers to Bronchial
asthma as Tamaka Shvasa. Asthma is a chronic
inflammatory disorder of the airways. In which the
chronic inflammation causes an associated increase
in airway hyper responsiveness that leads to
recurrent episodes of wheezing, breathlessness,
chest tightness and coughing, particularly at night
or in the early morning. These episodes are usually
associated with widespread but variable airflow
obstruction that is often reversible either
spontaneously or with treatment.
[1]
Asthma
prevalence is increased in very young persons and
very old persons because of airway responsiveness
and lower levels of lung function.
[2]
Asthma equally
affects both the sex in adult but in children male
female ratio is 2:1. Tamaka Shvasa is characterized
by difficulty in breathing. Difficulty in breathing is
due to the result of obstructed Pranavaha Srotasa.
The normal breathing is the function of Prakruta
Vata(Normal Vata), when it is aggravated due to
obstruction it produces abnormal breathing.
Tamaka Shvasa is having multifactorial origin
along with unwholesome diet, concentrated drinks,
cold drinks, smoking, environmental factors like
rains, cloudy weather, chilly wind etc. According
to modern medical science Asthma is a chronic
disease that cannot be cured but can be controlled
by avoid or control exposure to things that make
Asthma worse and use medication appropriately.
In Tamaka Shvasa, Shodhana(Purification)
procedure has given a due importance by almost all
Acharyas. But Shodhana therapy is not possible in
all the conditions and in all the patients, all time
and in the classics also, the Shamana(Pacification)
therapy has been considered better than Shodhana
and Brumhana(Nourishing) therapy. According to
Acharya Charaka the drug should be taken
Muhurmuhur(Frequently) in Shvasa Roga and Vati
(Tablet) can be administered easily by the patient.
So keeping this point in mind only Shamana
therapy is considered as therapeutic regime in this
study which has been designed to clinical study of
Amrutadi Vati and Vasadi Vati in the management
of Tamaka Shvasa w.s.r. to Bronchial asthma. In
present study, in Group A patients were
administered with a formulation namely Amrutadi
Vati [Table No1].
Name of
Drug
Botanical name
Part
used
Part
Guduchi
Tinospora
cordifolia
(Willd.)Miers
Stem
1
part
Nagarmotha
Cyprus rotundus
Linn.
Root
1
part
Bharangi
Clerodendrum
serratum
Linn.Moon
Root
1
part
Kantakari
Solanum
xanthocarpum
Schrad.& Wendl
Whole
plant
1
part
Tulasi
Ocimum
sanctum Linn.
Whole
plant
1
part
Pippali
Piper longum
Linn.
Fruit
1
part
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Amrutadi Vati is taken from Chakradatta Hikka
Shvasa Chikitsa Prakranam which contains
Guduchi, Nagarmotha, Bharangi, Kantakari,
Tulasi, Pippali.
[3]
In Group B patients were
administered with a formulation namely Vasadi
Vati [Table No.2].
Name of
Drug
Botanical name
Part
used
Part
Vasa
Adhatoda
vasica Nees
Whole
plant
1
part
Haridra
Curcuma longa
Linn.
Rhizo
me
1
part
Dhanyaka
Coriandrum
sativum Linn.
Seed
1
part
Guduchi
Tinospora
cordifolia
(Willd.) Miers.
Stem
1
part
Bharangi
Clerodendrum
serratum
Linn.Moon
Root
1
part
Pippali
Piper longum
Linn.
Fruit
1
part
Shunthi
Zingiber
officinale Roxb.
Rhizo
me
1
part
Kantakari
Solanum
xanthocarpum
Schrad.& Wendl
Whole
plant
1
part
Maricha
Piper nigrum
Linn.
Fruit
1
part
Vasadi Vati is taken from Yogaratnakar Shvasa
Chikitsa Adhyaya, which contains Vasa, Haridra,
Dhanyaka, Guduchi, Bharangi, Pippali, Shunthi,
Kantakari, Maricha.
[4]
In classics Both the drugs
were mentioned in the form of Kvatha (Decoction
form). But here the formulations are changed and is
considered in theform of Vati Kalpana (Tablet) .
Pharmacognostical study and Analytical study on
Drug Amrutadi vati and Vasadi vati were carried
out.
Aim:
To evaluate and compare the clinical effect of
Amrutadi vati and Vasadi vati in Tamaka shvasa.
Materials & Methods:
Selection of Patients :
Patients attending the O.P.D having complaints of
Tamaka Shvasa were selected, for the present study
for both the groups.
Inclusion criteria:
1. Patients having signs and symptoms of
Tamaka Shvasa described in Ayurvedic
texts and modern texts were included.
2. Patients of the age group of 16 to 70 years
were included.
Exclusion criteria:
1. Patients of age less than 16 & above 70 years.
2. Patients with status asthmaticus, asthma due to
cardiac origin.
3. Patients having complications like cor-
pulmonale, emphysema, pneumonia,
tuberculosis and malignancy etc. and
breathlessness due to diabetes mellitus, severe
anaemia, renal failure, major endocrine
disorders were excluded from the study.
Study Design:
Simple Random Sampling method was used for
selection of patients in clinical study.
Informed consent was taken from the patient before
including the patients in the trial.
Subjective Criteria :
Diagnosis was done on the basis of Classical
symptomatology of the disease Tamaka Shvasa and
cardinal symptoms of Bronchial asthma like
dyspnea, wheezing, chest tightness, coughing. A
special research proforma has been designed by
using Ayurvedic and modern parameters.
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Objective Criteria :
1. Laboratory investigations: Hb, CBC with
Absolute eosinophil count
2. Biochemical investigation
3. Spirometry
4. S. IgE test
5. Sputum test for exclusion of Tuberculosis if
necessary
6. Radiological examination
7. ECG for differential diagnosis with any
other disease if necessary
Criteria of Assessment:
The patients were examined weekly. Changes in
patient’s condition were noted & following points
were taken into consideration for the assessment of
the results.
1. Clinical features of Tamaka Shvasa were
assessed weekly till the end of treatment.
2. Hb%, CBC with Absolute Eosinophil
Count were carried out before & after
treatment.
3. S.IgE was carried out before and after
treatment in selected patients.
4. Spirometry was carried out before and after
treatment.
5. Effect of therapy was assessed on the basis
of Roga Bala(Disease strength), Deha
Bala(Body strength), Agni Bala(Digestive
power) & Satva Bala(Mind strength). Total
100 score was subdivided under Roga Bala
(60), Agni Bala (20), Deha Bala (10) &
Satva Bala (10). This score was further
subdivided into signs & symptoms
concerned with particulate factor.
Overall Assessment of Therapy:
Total score obtained in Rogabala, Dehabala,
Satvabala and Agnibala assessed in terms of-
0%-Unchanged
1-25%- Mild improvement
26-50%- Moderate improvement
51-75%- Marked improvement
76-100%- Complete remission
Follow-Up :
A follow-up study was carried out for 4 weeks.
Grouping/ Dose/ Anupana/ Kala/ Duration - In
Group-A patients were treated with Amrutadi Vati
[2tab. (500mg. each) thrice a day] with
Anupana(along with or after medicine) of luke
warm water for 8weeks. In Group-B patients were
treated with Vasadi Vati in similar dose, duration
and Anupana.
Pathya-Apathya: Proper diet and Pathya Apathya
will be advised to all the patient with specific cold
intake. It will be advised as per classics in both the
groups.
[5]
Pathya (Wholesome): Godhuma(Wheat),
Yava(Barley), Kulattha(Horse gram), Old Shathi
and Red Shali rice, Patola(Pointed gourd),
Rasona(Garlic), Tanduliyaka(Amaranthus
spinosus), Mulaka(Radish), Draksha(Grapes),
Amalaka(Emblica officinalis), Pakva Kapittha(Ripe
Wood apple), Nimbu(Lemon), Ushnodaka(Warm
water), Purana Sarpi(Old Ghee), Aja Ghrita(Goat
Ghee), Aja Paya(Goat milk), Madhu(Honey),
Snehana-Svedana(Oleation-Sudation).
Apathya(Unwholesome): Masha(Black gram),
Shakkarkanda(Sweet potato), Palandu(Onion),
Surana(Elephant foot yam), Sarshapa(Mustard),
Banana, Sheetodaka(Cold water), cold milk, curd
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preparations, ice creams, Vegavarodha(Suppression
of natural urges), Raja(Dust), Pragvata(East wind).
Observations:
Total 75 patients were registered for the present
study out of which 8 patients discontinued the
treatment. In Group A total 41 patients were
registered out of which 36 completed the treatment
and 05 discontinued and in Group B total 34
patients were registered out of them 31 completed
the treatment and 03 discontinued.
Maximum number of patients i.e. 30.67% were
belonged to age group of 41-50 years, 61.33% were
male, 82.67% were Hindu, 89.33% were married,
26.67% were educated up to primary, 38.67 % of
the patients were house wives, 56% were from
lower middle class, 8% patients had complaint of
aggravation in their symptoms due to heavy work
and 6.67% due to exposure of dust in occupation,
89.33% developed disease in Anupa Desha
(Marshy land), 84% were from urban habitat.
72% were vegetarian and 93.33% were having
regular diet habit. Maximum no. of patients i.e.
46.67% were having Vishamashana(taking food
irregularly or without following a particular time)
dietetic pattern, 68% were taking Katu Rasa
dominant diet (Pungent), 60% were taking Snigdha
Guna dominant diet (Unctuous), 53.33% of patients
were consuming Abhishyandi Ahara(Heavy to
digest and lead to obstruction), 50.67 % were
taking Guru Guna dominant diet(Heavy to digest),
13.33% were expose to Raja(Dust), 37.33%
patients reported to have Chinta(Stress), 82.67%
were not doing any exercise, 70.67% patients were
taking sleep 6-8 hrs per night, 69.33% were taking
day sleep, 92% were having regular bowel habit,
48% were having Vibandha(Constipation), 40%
were having Krura Koshtha(Difficult bowel
movements), 64% patients were having no
addiction, 45.33% of patients had past history of
allergy, 68% were taking inhaler as modern
medicine, 42.67% patients had positive family
history of asthma. 38.67% were having
KaphaVataja Prakriti and 57.33% were having
Tama dominant Prakriti, maximum patients had
Madhyama Sara (Average condition of tissue
health), Samhanana(Compactness), Pramana
(Measurement), Satmya(Suitability), Satva(Mental
constitution), Jarana Shakti(Digestive power) and
Vyayama Shakti(Examination of strength by
exercise). 61.33% patients were having Pravara
Abhyavaharana Shakti(Indicative of intake of food
quantity), 48% were having Vishamagni(Unstable
digestive fire). BMI 21-25 was observed in 40%
patients and BMI 25-30 was observed in 33.33%
patients. In chief complaints Shvasakashtata
(Dyspnoea) was found in 100% of the patients,
Pinasa(Cold) was present in 64%, Kasa
(productive)(Coughing) was present in 46.67%,
Parshvashula(Flank pain) was found in 44% while
Kasa (dry)(Coughing) was observed in 16%
patients. Associated symptoms like Ghurghurukam
(Wheezing) was found in 81.33% patients,
Vibandha(Constipation) was present in 48%
patients, Trisha(Thirst) was reported in 46.67%
patients, Kanthodhvansa(Itching in throat) was
observed in 33.33% patients, Griva
Shirasosamgrahanam (Restricted movement of
neck and head) was found in 32% patients.
Associated complaints during attack like
Krichchhernabhasitum (Difficulty in speaking) was
found in 77.33% patients, Lalate Sveda(Sweating
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on forehead) was present in 73.33%,
Vishushkasyata(Dryness of mouth) was present in
57.33%, Pramoha(Fainting and shock) was
reported in 29.33% patients and Parshvashula
(Flank pain) was observed in 21.33% patients.
Kaphapradhana Samprapti was observed in 64%
patients.Maximum patients i.e. 60% were suffering
from asthmatic attack on exertion and 52% during
night time. 1yr - 5yr chronicity was found in
38.67% patients. Vata Vriddhi Lakshana like
Ushnakamita (Desire for hot things) was present in
50.67% patients. Vata Kshaya Lakshana like
Utsaha hani(Loss of Enthusiasm) was present in
64% patients. Kapha Vriddhi Lakshana like
Shvasa(Breathlessness) was reported in 100%
patients. In Pranavaha Srotodushti Lakshana
maximum 81.33% patients having Sashabda
Shvasa(Stertrous respiration), In Udakavaha
Srotodushti Lakshana maximum 45.33% patients
having Ati Pipasa(Excessive thirst), in Annavaha
Srotodushti Lakshana maximum 46.67% patients
having Avipaka(Indigestion), in Rasavaha
Srotodushti Lakshana maximum 21.33% patients
having Angamarda(Body pain) while in
Purishavaha Srotodushti Lakshana maximum 28%
patients having Krichchhrapravritti of
Mala(Difficulty in passing the stool). Maximum
patients i.e. 53.33% had aggravation of symptoms
after taking cold drinks and 74.67% had
aggravation of symptoms of Tamaka Shvasa after
exposure to dust. 60% patients complaints of their
symptoms aggravate during winter season. In
relieving factors Asino Labhate Saukhyam was
found in 81.33% patients.
Absolute eosinophil count within normal limit in
60% patients, serum IgE within normal limit in
32.14% patients.
Spirometry findings: It was reported that out of
74patients undergone for spirometry test, FVC was
found <60% in 24.32% patients, between 60-80%
in 39.19% patients, >80% in 36.49% patients.
FEV1 was found <60% in 59.46% patients,
between 60-80% in 27.03% patients, >80% in
13.51% patients. FEV1% was found <60% in
22.97% patients, between 60-80% in 33.78%
patients, >80% in 43.24% patients and in 78.38%
patients PEF was <60%, between 60-80% in
12.16% patients and >80% in 9.46% patients.
Spirometry findings <60% suggests severe
persistent, 60-80% suggests moderate persistent
and >80% suggests mild persistent.
Results:
The results obtained were statistically analyzed and
percentage of relief was calculated. Wilcoxon
signed rank test was applied for all non-parametric
symptoms.
[6]
Students paired t test was applied for
objective parameters. ‘t’ values and ‘p’ values were
calculated by using the significance table.
Comparison of results between Group A & Group
B had been done by applying Students unpaired‘t’
test for the objective parameters and Chi square test
for the subjective parameters.
Level of Significance:
Significance
‘t’ test
(‘p’ Value)
Chi Square
(‘p’ Value)
Wilcoxon
Signed Rank
(‘p’ Value)
Non
significant
> 0.05,
< 0.1
> 0.05
> 0.05
Significant
≤ 0.05, ≤
0.01
≤ 0.05, ≤
0.01
≤ 0.05, <0.01
Highly
significant
≤ 0.001
≤ 0.001
≤ 0.001
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Effect of therapy on chief complaints (Figure-1)
Effect of therapy on chief complaints (Figure-1)
Relief in Shvasakashtata was 51.39% in Group A
while in Group B is 55.38%, which was statistically
highly significant in both the groups. In reducing
the frequency of Shvasakashtata 52.55% relief was
observed in Group A while Group B showed
56.45% relief. Both the groups provided
statistically highly significant relief in reducing the
frequency of Shvasakashtata. Group A showed
36.57% relief and Group B showed 37.10% relief,
which was statistically highly significant
improvement in reducing the duration of
Shvasakashtata in both groups. Group A showed
56.47% result on decreasing the dose of emergency
medicine whereas Group B showed 65.6% result,
which was statistically highly significant
improvement on decreasing the dose of emergency
medicine in both groups. Group A showed 69.23%
relief while Group B showed 72.22% relief in Kasa
(productive). Both the groups had provided
statistically highly significant improvement in Kasa
(productive). Group A showed 90% relief while
Group B showed 50% relief in Kasa (dry). Group A
had provided statistically significant improvement.
Group A showed 84.21% relief whereas Group B
showed 70.29% relief in Pinasa. Both the groups
had provided statistically highly significant
improvement in Pinasa. In Group A 88.89% relief
was found while Group B showed 83.33% relief in
Parshvashula. Group A showed statistically highly
significant improvement while Group B showed
statistically significant improvement.
Effect of therapy on associated complaints:
(Figure-2)
Effect of therapy on associated complaints(Figure-2)
Group A showed 79.17% relief while in Group B
87.5% relief was found in
GrivaShirasosamgrahanam. Both the groups had
provided statistically significant improvement in
GrivaShirasosamgrahanam. In Group A 83.33%
relief was found in Kanthodhvansa whereas Group
B showed 63.64% relief and Group A had provided
statistically highly significant improvement while
Group B had provided statistically significant
improvement in Kanthodhvansa. Group A showed
61.90% relief whereas Group B showed 43.59%
relief in Trisha and Group A had provided
statistically highly significant improvement while
Group B had provided statistically significant
improvement in Trisha. In Group A 80% relief was
found whereas Group B showed 84.03% relief in
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Ghurghurukam. Both the groups had provided
statistically highly significant relief in
Ghurghurukam.
Effect of therapy on relieving factors: (Figure-3)
Effect of therapy on relieving factors (Figure-3)
Ushnabhinandati(Likes hot things): - Group A
showed 40.48% relief while Group B showed
30.77% relief in taking hot things as relieving
factors. Both the groups had provided statistically
significant improvement in Ushnabhinandati.
Group A showed 62.5 % relief whereas in Group B
54.17% relief was found in decrease in Shleshma
Vimokshante Labhate Sukham(feeling better after
expectorating sputum),. Both the groups had
provided statistically highly significant
improvement in Shleshma Vimokshante Labhate
Sukham.
Asino Labhate Saukhyam(Feels comfortable in the
sitting position): - Group A showed 46.55% relief
whereas Group B showed 34.62% relief. Group A
had provided statistically highly significant
improvement while Group B had provided
statistically significant improvement in Asino
Labhate Saukhyam. Thus, it can be concluded that
both the groups had provided almost equal effect on
Asino Labhate Saukhyam. Group A showed 61.62%
relief whereas Group B showed 68.68% relief in
Rhonchi. Both the groups had provided statistically
highly significant relief in Rhonchi.
In Agni Bala Pariksha, In Group A highly
significant relief was found in Jarana Shakti
(65.28%) and Vata Mutra Purisha Mukti (Passes
gas, urine and stool properly)(82.35%). Effect on
Abhyavaharana Shakti was 33.33%. It was not
possible to analyze data in Abhyavaharana Shakti
because the SD in Group A is Zero.In Group-B,
highly significant relief was found in Jarana Shakti
(57.18%) and significant relief was found in
Abhyavaharana Shakti (41.67%) and Vata Mutra
Purisha Mukti (66.67%). Effect on Ruchi Hi
Aharakale(likes eating/proper appetite on proper
timing) was 29.63% in Group-A and It was not
possible to analyze data on effect on Ruchi Hi
Aharakale because the SD is Zero, While Effect on
Ruchi Hi Aharakale was 30% in Group-B and It
was not possible to analyze data on effect on Ruchi
Hi Aharakale because the SD is Zero.
In Group-A, Highly significant relief was found in
Deha Bala Pariksha i.e., Bala Vriddhi (Increased
strength)(70.83%) and Svara Varna Yoga(Good
complexion and voice) (73.33%). No change was
observed in Sharira Upachaya. While in Group-B,
Highly significant relief was found in Deha Bala
Pariksha i.e., Bala Vriddhi (71.01%) and Svara
Varna Yoga (71.43%). No change was observed in
Sharira Upachaya.
In Group-A, Highly significant relief was found in
Satva Bala Pariksha i.e., Nidra Labho
Yathakalam(Proper sleep on its perfect time)
(86.46%), Sukhena Cha Pratibodhanam (Waking
up happily without any lethargy)(66.67%) and
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Mano Buddhi Indriya Avyapatti(Mind, intellect and
senses in good state) (78%) and insignificant relief
was found in Vaikarikanam Cha Svapnanam
Adarshanam(No bad dreams/No dreams) (22.73%),
While in Group-B, Highly significant relief was
found in Satva Bala Pariksha i.e., Sukhena Cha
Pratibodhanam (65.22%), Mano Buddhi Indriya
Avyapatti (60.87%) and insignificant relief was
found in Nidra Labho Yathakalam (47.62%),
Vaikarikanam Cha Svapnanam Adarshanam
(31.82%)
In present study it was found that Group A
provided maximum relief in Vata Dosha Dushti
esp. 68.52% in Alpabalatva(Low strength), 78% in
Utsaha Hani and in Pitta Dosha Dushti esp.
78.57% improvement in
Alpanidrata(Less/disturbed sleep), Kapha Dosha
Dushti esp. 76.09% in Kasa, 62.5% in Trishna.
While Group B showed maximum relief in Kapha
Dosha Dushti esp. 51.61% in Shvasa. In Pranavaha
Srotasa Dushti Lakshana maximum relief was
found in Sashula Shvasa (Painful
breathing)(100%), Udakavaha Srotasa Dushti
Lakshana maximum relief was found in Jihva-
Talu-Aushtha-Kantha-Kloma Shosha(Dryness in
tongue, palate, lips, throat and kloma(Respiratory
tract)) (85.71%), In Annavaha Srotasa Dushti
Lakshana maximum relief was found in
Avipaka(Indigestion) (55.88%), In Purishavaha
Srotasa Dushti Lakshana maximum relief was
found in Ati Grathita Malapravritti(Excessive hard
stool) (88.89%) in Group-A. While In Pranavaha
Srotasa Dushti Lakshana maximum relief was
found in Sashula Shvasa (87.5%), Udakavaha
Srotasa Dushti Lakshana maximum relief was
found in Ati pipasa (42.31%), In Annavaha Srotasa
Dushti Lakshana maximum relief was found in
Avipaka (66.67%). In Purishavaha Srotasa Dushti
Lakshana maximum relief was found in
Krichchhrapravritti of Mala (75%) in Group-B.
In Group-A Significant changes were found in
S.Cholesterol and Total Protein and in spirometry
all the objective parameters were insignificantly
changed while in Group-B Significant changes
were found in FEV1% and remaining objective
parameters were insignificantly changed. (Table-
3,4,5.6)
Table No. 3: Effect of Amrutadi Vati on
spirometric parameters (Paired‘t’ test)
(AT:After treatment; BT: Before treatment; DF:Difference; SD: Standard
deviation; SE: Standard error; IS: Insignificant, FVC: Forced Vital capacity,
FEV1:Forced expiratory volume in the first second; PEF: Peak expiratory
flow )
Table No.4: Effect of Vasadi Vati on spirometric
parameters (Paired‘t’ test)
(AT:After treatment; BT: Before treatment; DF:Difference; SD: Standard
deviation; SE: Standard error; IS: Insignificant, FVC: Forced Vital capacity,
FEV1:Forced expiratory volume in the first second; PEF: Peak expiratory
flow )
Inve
stio
n
Mean
values
M
ea
n
D.
F.
%
cha
nge
S.
D.
S.
E.
‘t’
P
Si
g.
B.
T.
A.
T.
FVC
78.
171
75.
200
2.9
71
1.36
0↓
17.
180
2.9
04
1.0
23
0.3
13
IS
FEV
1
57.
886
56.
286
1.6
00
1.25
4↓
13.
412
2.2
67
0.7
06
0.4
85
IS
FEV
1%
75.
943
76.
857
0.9
14
3.00
3↑
11.
579
1.9
57
-
0.4
67
0.6
43
IS
PEF
50.
171
44.
286
5.8
86
1.67
7↓
17.
801
3.0
09
1.9
56
0.0
59
IS
Inve
stio
n
Mean
values
M
ea
n
D.
F.
%
cha
nge
S.
D.
S.
E.
‘t’
P
Si
g.
B.
T.
A.
T.
FVC
76.
032
75.
452
0.5
81
0.52
0↓
11.7
47
2.1
10
0.2
75
0.7
85
IS
FEV
1
52.
806
55.
774
2.9
68
8.93
6↑
12.
916
2.3
20
-
1.2
79
0.2
11
IS
FEV
1%
72.
194
76.
935
4.7
42
9.17
0↑
12.
662
2.2
74
-
2.0
85
0.0
46
S
PEF
44.
194
42.
839
1.3
55
5.77
0↓
18.
288
3.2
85
0.4
12
0.6
83
IS
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18
Table No.5: Effect of AMRUTADI VATI In
Haematological Parameters in Patients - By
Paired t Test
(N-Number; AT:After treatment; BT: Before treatment; D:Difference; SD:
Standard deviation; SE: Standard error; IS: Insignificant, S:Significant, Hb
gms-Grams of Hemoglobin; TLC-Total leucocyte cell;Cumm-Cubic
millimeter;N-Neutrophils;L-Lymphocytes;E-Eosinophils;M-Monocytes;ESR
mm at 1
st
hr-Erythrocyte sedimentation rate in millimeters per hour;S.chole-
Serum Cholesterol;S.creat-Serum creatinine;S.IgE-Serum Immunoglobulin E;
;A.E.C-Absolute Eosinophil count )
Table-6: Effect of VASADI VATI In
Haematological Parameters in Patients - By
Paired t Test
(N-Number; AT:After treatment; BT: Before treatment; D:Difference; SD:
Standard deviation; SE: Standard error; IS: Insignificant, S:Significant, Hb
gms-Grams of Hemoglobin; TLC-Total leucocyte cell;Cumm-Cubic
millimeter;N-Neutrophils;L-Lymphocytes;E-Eosinophils;M-Monocytes;ESR
mm at 1
st
hr-Erythrocyte sedimentation rate in millimeters per hour;S.chole-
Serum Cholesterol;S.creat-Serum creatinine;S.IgE-Serum Immunoglobulin E;
;A.E.C-Absolute Eosinophil count )
Effect of therapy on follow up: It was observed
that recurrence was found in 61.11% patients in
Group A and 55.22% patients in Group B during
one month follow up. Thus, it can be concluded
that Group B had long lasting effects in comparison
to Group A.
Comparative study of both groups:
In present study Chi square was applied for all
subjective parameters. It was found that
insignificant difference was found between effect
of therapies of both the groups in Shvasakashtata,
decreasing the frequency of Shvasakashtata,
reduction of duration of Shvasakashtata, reduction
in no. of emergency medicine taken/week,
Kasa(productive), Kaphanishthivana, Pinasa,
Parshvashula, Griva Shirasosamgrahanam,
Kanthodhvansa, Trisha, Ghurghurukam,
Ushnabhinandati, Shleshma Vimokshante Labhate
Sukham, Asino Labhate Saukhyam, Rhonchi, Agni
Bala, Deha Bala, Satva Bala, Vata Dosha Dushti
Lakshana, Kapha Dosha Dushti Lakshana,
Pranavaha Srotasa Dushti Lakshana, Udakavaha
Srotasa Dushti Lakshana, Purishavaha Srotasa
Dushti Lakshana. Thus, both groups showed almost
similar effect on above symptoms but there was
significant difference found between both groups
on Nidra Labho Yathakalam. Group A showed
better relief than Group B on Nidra Labho
Yathakalam.
Overall effect of therapy:
In present study it was observed that complete
remission was found in 19.44% patients in Group A
and 19.36% patients in Group B. Marked
improvement was found in 41.67% patients in
Group A and 29.03% patients in Group B.
Moderate improvement was found in 30.56%
Investigations
N
Mean Score
%
Relief
S.D.
S.E.
‘t’
Sig.
B.T.
A.T.
D
Hb gms%
36
13.322
13.364
0.042
0.388 ↑
0.608
0.101
-0.411
IS
TLC /Cumm
36
8019.44
8091.66
72.22
1.17↑
1936.66
322.78
-0.224
IS
N %
36
56.917
57.361
0.444
1.182 ↑
7.496
1.249
-0.356
IS
L %
36
35.194
34.139
1.056
1.713 ↓
6.990
1.165
0.906
IS
E %
36
5.194
5.694
0.500
12.146↑
2.613
0.436
-1.148
IS
M %
36
2.694
2.639
0.056
0.185 ↓
0.630
0.105
0.529
IS
ESR -mm at
1
st
hr
36
23.278
23.056
0.222
16.446↓
17.862
2.977
0.0746
IS
S. Chole.
36
171.833
160.500
11.333
5.487↓
22.668
3.778
3.000
S
S. creat.
36
0.983
0.969
0.014
0.697↓
0.0961
0.0160
0.867
IS
Total Protein
36
6.903
6.794
0.108
1.510↓
0.278
0.0464
2.337
S
S.IgE
13
875.131
731.100
144.031
5.454↓
314.475
87.220
1.651
IS
A.E.C
36
418.056
443.056
25.000
18.468↑
226.306
37.718
-0.663
IS
Investigations
N
Mean Score
%
Relief
S.D.
S.E.
‘t’
P
value
B.T.
A.T.
D
Hb gms%
31
13.303
13.455
0.152
1.247↑
0.672
0.121
-
1.257
IS
TLC/Cumm
31
8322.58
7903.23
419.36
3.43↓
1824.91
327.76
1.279
IS
N %
31
61.968
61.323
0.645
0.247↓
10.062
1.807
0.357
IS
L %
31
30
30.290
0.290
5.499↑
8.893
1.597
-
0.182
IS
E %
31
5.968
5.806
0.161
17.301↓
3.734
0.671
0.241
IS
M %
31
2.710
2.581
0.129
2.688 ↓
0.562
0.101
1.278
IS
ESR -mm at
1
st
hr
31
25.484
26.645
1.161
51.163↑
21.434
3.850
-
0.302
IS
S. Chole
31
168.645
179.194
10.548
6.525↑
29.961
5.381
-
1.960
IS
S. creat.
31
1.029
1.006
0.0226
0.163↓
0.143
0.0257
0.879
IS
Total Protein
31
6.881
6.903
0.0226
0.461↑
0.297
0.0534
-
0.423
IS
S.IgE
14
688.493
749.171
60.679
3.221↑
202.697
54.173
-
1.120
IS
A.E.C
31
487.097
456.452
30.645
12.717↓
294.584
52.909
0.579
IS
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19
patients in Group A and 45.16% patients in Group
B. Mild improvement was found in 8.33% patients
in Group A and 6.45% patients in Group B. Not a
single patient remained unchanged in both the
groups. Thus, it can be concluded that Group A
provided marked improvement followed by
moderate improvement in maximum patients while
Group B provided moderate improvement followed
by marked improvement in maximum patients.
Probable Mode of action of Amrutadi vati The
overall pharmacodynamics of Amrutadi Vati are
i.e. Katu Rasa (83.33%), Tikta Rasa (100%), Laghu
Guna (100%), Ushna Virya (66.67%), Katu Vipaka
(66.67%), Kaphavatashamaka (83.33%). These
pharmacodynamic actions are helpful in breaking
the pathogenesis of Tamaka Shvasa. Formulation
comprises of group of drugs, and hence when
considering the overall effect of the preparation, it
can be either individual effect of a drug or a
combined effect of it. The probable mode of action
of ingredients of Amrutadi Vati is summarized as
below. In Amrutadi Vati combination of Vata-
Kaphahara Rasapanchaka of the drugs pacify both
the causative Doshas. Amrutadi Vati relieving the
symptoms of Tamaka Shvasa by its
Vatakaphahara, Deepana, Pachana and
Vatanulomana properties. Vata-Kaphahara
property of most of the content alleviates both Vata
and Kapha, which are the main causative Doshas in
the Samprapti of Tamaka Shvasa. The main factor
in this disease is Ama and the Deepana-Pachana
properties of the drug will digest the Ama by
kindling the Jatharagni as well as Rasagni and
Bhutagni. Further the Shothaharatva Karma of
most of the contents will neutralize the Srotorodha
in Pranavahasrotasa due to Shotha created by
Sama Vata.
The main logics behind the actions are:
1. The Dosha-Prashamana effect (Guduchi,
Bharangi, Kantakari, Tulasi, Pippali) acts
on the main Doshas which contribute to the
Samprapti viz. Vata and Kapha.
2. Deepana Karma (Guduchi, Nagarmotha,
Bharangi, Kantakari, Tulasi, Pippali) and
Pachana Karma (Nagarmotha, Bharangi,
Kantakari) digest Ama.
3. Vatanulomana property (Pippali) maintains
the normal flow of Vata.
4. Shvasahara and Kasahara Prabhava -
(Nagarmotha, Bharangi, Kantakari, Tulasi,
Pippali) act on the symptoms.
5. Shothahara Prabhava- Kantakari.
Probable Mode of action of Vasadi vati
The overall pharmacodynamics of Vasadi Vati are
i.e. Tikta Rasa (88.89%), Katu Rasa (77.78%),
Laghu Guna (88.89%), Ushna Virya (77.78%),
Katu Vipaka 55.56%), Madhura Vipaka (44.44%),
KaphaVatashamaka (77.78%).
The probable mode of action of ingredients of
Vasadi Vati:
In Vasadi Vati combination of Vata-Kaphahara
Rasapanchaka of the drugs pacify both the
causative Doshas. In Vasadi vati most of contains
have Tikta Rasa, Laghu Guna, Katu Vipaka and
Vata-kaphahara properties. Tikta Rasa has the
property of Deepana, Pachana and Kaphaghna.
[7]
Thus, helps in Amanashana formed due to
Nidanasevana. Laghu Guna and Katu Vipaka
possess Kaphashamaka and Srotoshodhaka
property which acts on minute channels and
removes the Amavisha. Further the Shothaharatva
Karma of most of the contents will neutralize the
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Srotorodha in Pranavaha Srotasa due to Shotha
created by Sama Vata. Thus, Vasadi Vati relieving
the symptoms of Tamaka Shvasa by its
Vatakaphahara, Deepana, Pachana and
Vatanulomana properties.
The main logics behind the actions are:
1. The Dosha-Prashamana effect (Dhanyaka,
Guduchi, Bharangi, Pippali, Shunthi,
Kantakari, Maricha) acts on the main
Doshas which contribute to the Samprapti
viz. Vata and Kapha.
2. Deepana Karma (Dhanyaka, Guduchi,
Bharangi, Pippali, Shunthi, Kantakari,
Maricha) and Pachana Karma (Dhanyaka,
Bharangi, Shunthi, Kantakari) digest Ama.
3. Vatanulomana property (Pippali, Shunthi)
maintains the normal flow of Vata.
4. Shvasahara Prabhava (Vasa, Bharangi,
Pippali, Shunthi, Kantakari, Maricha) and
Kasahara (Vasa, Bharangi, Pippali,
Kantakari) act on the symptoms.
5. Shothahara Prabhava- Kantakari.
Discussion:
Tamaka Shvasa is a Vatakaphatmaka Vyadhi and
the properties of both the Doshas are opposite to
each other (besides Sheeta Guna) so a combination
of Vata Kaphahara Rasapanchaka of the drugs
pacify both the causative Doshas and relieving the
symptoms. Tamaka Shvasa is having Kapha, Vata
predominance. Acharyas have mentioned that those
diet & drugs which are having KaphaVataghna,
Ushna & Vatanulomana properties are useful in the
management of Shvasa
[8]
. As in the pathogenesis
of this disease, Mandagni leads to the formation of
Ama, which results in the formation of Malarupa
Kapha producing the obstruction in the normal path
of Vata for that Arundatta has mentioned role of
Deepana- Pachana drugs in the management of
Tamaka ShvasaAmrutadi vati has Kapha,
Vatashamaka property by Katu, Tikta Rasa and
Ushnavirya and Vasadi Vati has Kaphashamaka
property by Katu, Tikta Rasa and Vatashamaka
property by Ushnavirya. Katu Rasa causes
Deepana, Pachana, Rochana, Srotoshodhana and
Kaphaghna action. The Deepana and Pachana
properties of formulation control the initial Ama
formation which is very important in preventing the
disease. Most of the Dravyas possess Ushna Virya
which pacifies Sheeta Guna of Vata and Kapha.
Katu Vipaka is Laghu Vipaka possessing Laghu,
Ruksha, Vishada and Tikshna Gunas which pacifies
Kapha. Most of the drugs possess Laghu Guna.
Laghu Guna is Kaphahara; it decreases Mala and
clears the channels (Srotasa-Shodhana) and also
improved digestion. On the psyche (Manasa) it has
positive effect by improving activeness and
providing inspiration. Vatanulomana property of
drugs corrects Pratiloma Gati of Vata and
maintains its normal Gati.
Conclusion :
In present study, Maximum patients were of
KaphaVataja Prakriti and Tama dominant Prakriti
which indicates its more susceptibility for Tamaka
shvasa. Maximum patients reported for
Divasvapna(Day sleep). Divasvapna leads to
improper digestion, Ama production which leads to
the pathogenesis of Asthma. Amrutadi vati and
Vasadi vati showed equal effect in most of the
symptoms but Amrutadi vati showed significantly
better relief in Nidra Labho Yathakalam. From this
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21
study it can be concluded that both the groups
would be useful in Kaphapradhana Sampratijanya
Tamaka Shvasa. This work can be helpful in
management of a distressing condition Tamaka
Shvasa (Bronchial Asthma) which causes disability
and distress to the human being due to serious
impairment in day to day life. No any adverse
effect was found in both the trial drugs but further
Amrutadi Vati proved as more effective in the
patient of Tamaka Shvasa in compare to Vasadi
Vati.
References:
1. GINA workshop report (updated 2004) Chapter-
1.
2. Burrows B, Barbee RA, Cline MG, Knudson RJ,
Lebowitz MD. Characteristics of asthma among
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3. Chakradatta, by Dr. Indradev Tripathi, Published
by Chaukhambha Sanskrit bhavan, Edition-
Reprint 2010 ,Chapter 12, pg no.108.
4. Yogaratnakara by Vaidya Lakshmipati Shastri,
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Reprint 2009, Shvasa Chikitsa adhyaya, pg
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Published by Chaukhambha Prakashan, Edition-
Reprint 2009 , Shvasa Chikitsa adhyaya ,
pg.no.435.
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and Dridhbala with ‘Ayurveda Dipika’
commentary by Chakrapanidatta, Edited by
Trivikram Atmaja Yadav Sharma, Published by
Rashtriya Sanskrit Samsthana, Chaukhambha
Publications New Delhi, Year of reprint 2006,
Sutra Sthana 26/5, pg no.144.
8. Agnivesha,Charaka Samhita, revised by Charaka
and Dridhbala with ‘Ayurveda Dipika’
commentary by Chakrapanidatta, Edited by
Trivikram Atmaja Yadav Sharma, Published by
Rashtriya Sanskrit Samsthana, Chaukhambha
Publications New Delhi, Year of reprint 2006,
Chikitsasthana 17/147, pg no.539.
Declaration :
Conflict of Interest : None
ISSN: 2584-2757
DOI : 1 0 . 5 2 8 1 / z e n o d o . 1 7 3 5 8 6 88
Dr.Kapadiya Parul R.
Inter. J.Digno. and Research
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